Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4742157..4742673 Replicon chromosome
Accession NZ_OW970514
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQ358_RS23130 Protein ID WP_009486548.1
Coordinates 4742157..4742441 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQ358_RS23135 Protein ID WP_002886901.1
Coordinates 4742431..4742673 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ358_RS23105 (4737574) 4737574..4737837 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQ358_RS23110 (4737967) 4737967..4738140 + 174 WP_032433782.1 hypothetical protein -
LQ358_RS23115 (4738143) 4738143..4738886 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQ358_RS23120 (4739243) 4739243..4741381 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQ358_RS23125 (4741689) 4741689..4742153 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ358_RS23130 (4742157) 4742157..4742441 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ358_RS23135 (4742431) 4742431..4742673 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ358_RS23140 (4742751) 4742751..4744661 - 1911 WP_229976683.1 PRD domain-containing protein -
LQ358_RS23145 (4744684) 4744684..4745838 - 1155 WP_002886900.1 lactonase family protein -
LQ358_RS23150 (4745905) 4745905..4746645 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296429 WP_009486548.1 NZ_OW970514:c4742441-4742157 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296429 WP_002886901.1 NZ_OW970514:c4742673-4742431 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References