Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4638356..4639166 Replicon chromosome
Accession NZ_OW970514
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LQ358_RS22600 Protein ID WP_002887280.1
Coordinates 4638356..4638889 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LQ358_RS22605 Protein ID WP_002887278.1
Coordinates 4638900..4639166 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ358_RS22595 (4637188) 4637188..4638309 + 1122 WP_009309849.1 cupin domain-containing protein -
LQ358_RS22600 (4638356) 4638356..4638889 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
LQ358_RS22605 (4638900) 4638900..4639166 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LQ358_RS22610 (4639269) 4639269..4640702 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
LQ358_RS22615 (4640692) 4640692..4641375 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
LQ358_RS22620 (4641548) 4641548..4642933 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
LQ358_RS22625 (4642951) 4642951..4643256 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T296428 WP_002887280.1 NZ_OW970514:c4638889-4638356 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296428 WP_002887278.1 NZ_OW970514:c4639166-4638900 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References