Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2740486..2742074 Replicon chromosome
Accession NZ_OW970514
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQ358_RS13505 Protein ID WP_002904792.1
Coordinates 2740486..2741808 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQ358_RS13510 Protein ID WP_002904790.1
Coordinates 2741808..2742074 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ358_RS13490 (2735542) 2735542..2738043 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQ358_RS13495 (2738031) 2738031..2739035 + 1005 WP_032433097.1 fimbrial protein -
LQ358_RS13500 (2739177) 2739177..2740469 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQ358_RS13505 (2740486) 2740486..2741808 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQ358_RS13510 (2741808) 2741808..2742074 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQ358_RS13515 (2742460) 2742460..2742786 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQ358_RS13520 (2742783) 2742783..2743283 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQ358_RS13525 (2743261) 2743261..2744640 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQ358_RS13530 (2744986) 2744986..2746140 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQ358_RS13535 (2746121) 2746121..2747044 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296426 WP_002904792.1 NZ_OW970514:c2741808-2740486 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296426 WP_002904790.1 NZ_OW970514:c2742074-2741808 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References