Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1502344..1503080 Replicon chromosome
Accession NZ_OW970514
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQ358_RS07490 Protein ID WP_032433360.1
Coordinates 1502598..1503080 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQ358_RS07485 Protein ID WP_003026799.1
Coordinates 1502344..1502610 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ358_RS07460 (1497990) 1497990..1499129 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQ358_RS07465 (1499158) 1499158..1499820 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQ358_RS07470 (1499801) 1499801..1500808 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQ358_RS07475 (1500826) 1500826..1501458 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQ358_RS07480 (1501468) 1501468..1502031 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQ358_RS07485 (1502344) 1502344..1502610 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQ358_RS07490 (1502598) 1502598..1503080 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQ358_RS07495 (1503280) 1503280..1504683 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQ358_RS07500 (1504712) 1504712..1505344 - 633 WP_060591614.1 hypothetical protein -
LQ358_RS07505 (1505724) 1505724..1506323 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQ358_RS07510 (1506536) 1506536..1507480 - 945 WP_077254249.1 fimbrial protein -
LQ358_RS07515 (1507492) 1507492..1507752 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1472567..1516155 43588
- flank IS/Tn - - 1503280..1504683 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296421 WP_032433360.1 NZ_OW970514:1502598-1503080 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296421 WP_003026799.1 NZ_OW970514:1502344-1502610 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References