Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834892..835549 Replicon chromosome
Accession NZ_OW970514
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQ358_RS04185 Protein ID WP_002916310.1
Coordinates 835139..835549 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQ358_RS04180 Protein ID WP_002916312.1
Coordinates 834892..835158 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ358_RS04155 (830048) 830048..831481 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LQ358_RS04160 (831600) 831600..832328 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQ358_RS04165 (832378) 832378..832689 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQ358_RS04170 (832853) 832853..833512 + 660 WP_002916317.1 hemolysin III family protein -
LQ358_RS04175 (833663) 833663..834646 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQ358_RS04180 (834892) 834892..835158 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQ358_RS04185 (835139) 835139..835549 + 411 WP_002916310.1 protein YgfX Toxin
LQ358_RS04190 (835556) 835556..836077 - 522 WP_004144730.1 flavodoxin FldB -
LQ358_RS04195 (836178) 836178..837074 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQ358_RS04200 (837097) 837097..837810 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ358_RS04205 (837816) 837816..839549 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296419 WP_002916310.1 NZ_OW970514:835139-835549 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296419 WP_002916312.1 NZ_OW970514:834892-835158 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References