Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5202815..5203440 Replicon chromosome
Accession NZ_OW970492
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LQV37_RS25370 Protein ID WP_002882817.1
Coordinates 5202815..5203198 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LQV37_RS25375 Protein ID WP_004150355.1
Coordinates 5203198..5203440 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV37_RS25355 (5200181) 5200181..5201083 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LQV37_RS25360 (5201080) 5201080..5201715 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LQV37_RS25365 (5201712) 5201712..5202641 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQV37_RS25370 (5202815) 5202815..5203198 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV37_RS25375 (5203198) 5203198..5203440 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LQV37_RS25380 (5203645) 5203645..5204562 + 918 WP_021466676.1 alpha/beta hydrolase -
LQV37_RS25385 (5204576) 5204576..5205517 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LQV37_RS25390 (5205562) 5205562..5205999 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LQV37_RS25395 (5205996) 5205996..5206856 - 861 WP_004146232.1 virulence factor BrkB family protein -
LQV37_RS25400 (5206850) 5206850..5207449 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296414 WP_002882817.1 NZ_OW970492:c5203198-5202815 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT296414 WP_004150355.1 NZ_OW970492:c5203440-5203198 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References