Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4758164..4758680 Replicon chromosome
Accession NZ_OW970492
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV37_RS23235 Protein ID WP_009486548.1
Coordinates 4758164..4758448 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV37_RS23240 Protein ID WP_002886901.1
Coordinates 4758438..4758680 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV37_RS23210 (4753581) 4753581..4753844 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV37_RS23215 (4753974) 4753974..4754147 + 174 WP_032433782.1 hypothetical protein -
LQV37_RS23220 (4754150) 4754150..4754893 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV37_RS23225 (4755250) 4755250..4757388 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV37_RS23230 (4757696) 4757696..4758160 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV37_RS23235 (4758164) 4758164..4758448 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV37_RS23240 (4758438) 4758438..4758680 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV37_RS23245 (4758758) 4758758..4760668 - 1911 WP_009486549.1 PRD domain-containing protein -
LQV37_RS23250 (4760691) 4760691..4761845 - 1155 WP_002886900.1 lactonase family protein -
LQV37_RS23255 (4761912) 4761912..4762652 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296413 WP_009486548.1 NZ_OW970492:c4758448-4758164 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296413 WP_002886901.1 NZ_OW970492:c4758680-4758438 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References