Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4654363..4655173 Replicon chromosome
Accession NZ_OW970492
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LQV37_RS22705 Protein ID WP_002887280.1
Coordinates 4654363..4654896 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LQV37_RS22710 Protein ID WP_002887278.1
Coordinates 4654907..4655173 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV37_RS22700 (4653195) 4653195..4654316 + 1122 WP_009309849.1 cupin domain-containing protein -
LQV37_RS22705 (4654363) 4654363..4654896 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
LQV37_RS22710 (4654907) 4654907..4655173 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LQV37_RS22715 (4655276) 4655276..4656709 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
LQV37_RS22720 (4656699) 4656699..4657382 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
LQV37_RS22725 (4657555) 4657555..4658940 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
LQV37_RS22730 (4658958) 4658958..4659263 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T296412 WP_002887280.1 NZ_OW970492:c4654896-4654363 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296412 WP_002887278.1 NZ_OW970492:c4655173-4654907 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References