Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2767709..2769297 Replicon chromosome
Accession NZ_OW970492
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQV37_RS13650 Protein ID WP_002904792.1
Coordinates 2767709..2769031 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQV37_RS13655 Protein ID WP_002904790.1
Coordinates 2769031..2769297 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV37_RS13635 (2762765) 2762765..2765266 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQV37_RS13640 (2765254) 2765254..2766258 + 1005 WP_032433097.1 fimbrial protein -
LQV37_RS13645 (2766400) 2766400..2767692 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV37_RS13650 (2767709) 2767709..2769031 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV37_RS13655 (2769031) 2769031..2769297 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV37_RS13660 (2769683) 2769683..2770009 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQV37_RS13665 (2770006) 2770006..2770506 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV37_RS13670 (2770484) 2770484..2771863 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQV37_RS13675 (2772209) 2772209..2773363 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV37_RS13680 (2773344) 2773344..2774267 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296410 WP_002904792.1 NZ_OW970492:c2769031-2767709 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296410 WP_002904790.1 NZ_OW970492:c2769297-2769031 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References