Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1514768..1515504 Replicon chromosome
Accession NZ_OW970492
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV37_RS07560 Protein ID WP_032433360.1
Coordinates 1515022..1515504 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV37_RS07555 Protein ID WP_003026799.1
Coordinates 1514768..1515034 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV37_RS07530 (1510414) 1510414..1511553 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV37_RS07535 (1511582) 1511582..1512244 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV37_RS07540 (1512225) 1512225..1513232 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV37_RS07545 (1513250) 1513250..1513882 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV37_RS07550 (1513892) 1513892..1514455 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV37_RS07555 (1514768) 1514768..1515034 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV37_RS07560 (1515022) 1515022..1515504 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV37_RS07565 (1515704) 1515704..1517107 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV37_RS07570 (1517136) 1517136..1517768 - 633 WP_060591614.1 hypothetical protein -
LQV37_RS07575 (1518148) 1518148..1518747 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV37_RS07580 (1518960) 1518960..1519904 - 945 WP_077254249.1 fimbrial protein -
LQV37_RS07585 (1519916) 1519916..1520176 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1483437..1528579 45142
- flank IS/Tn - - 1515704..1517107 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296405 WP_032433360.1 NZ_OW970492:1515022-1515504 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296405 WP_003026799.1 NZ_OW970492:1514768-1515034 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References