Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4848917..4849433 Replicon chromosome
Accession NZ_OW970486
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV31_RS23730 Protein ID WP_009486548.1
Coordinates 4848917..4849201 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV31_RS23735 Protein ID WP_002886901.1
Coordinates 4849191..4849433 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV31_RS23705 (4844334) 4844334..4844597 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV31_RS23710 (4844727) 4844727..4844900 + 174 WP_032433782.1 hypothetical protein -
LQV31_RS23715 (4844903) 4844903..4845646 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV31_RS23720 (4846003) 4846003..4848141 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV31_RS23725 (4848449) 4848449..4848913 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV31_RS23730 (4848917) 4848917..4849201 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV31_RS23735 (4849191) 4849191..4849433 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV31_RS23740 (4849511) 4849511..4851421 - 1911 WP_009486549.1 PRD domain-containing protein -
LQV31_RS23745 (4851444) 4851444..4852598 - 1155 WP_002886900.1 lactonase family protein -
LQV31_RS23750 (4852665) 4852665..4853405 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296398 WP_009486548.1 NZ_OW970486:c4849201-4848917 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296398 WP_002886901.1 NZ_OW970486:c4849433-4849191 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References