Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1496402..1497045 Replicon chromosome
Accession NZ_OW970486
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV31_RS07435 Protein ID WP_032433387.1
Coordinates 1496629..1497045 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV31_RS07430 Protein ID WP_001261276.1
Coordinates 1496402..1496632 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV31_RS07415 (1491424) 1491424..1492511 + 1088 Protein_1452 transcriptional repressor PifC -
LQV31_RS07420 (1492514) 1492514..1494754 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV31_RS07425 (1495282) 1495282..1496097 - 816 WP_032433388.1 hypothetical protein -
LQV31_RS07430 (1496402) 1496402..1496632 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV31_RS07435 (1496629) 1496629..1497045 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV31_RS07440 (1497201) 1497201..1498181 + 981 WP_032433385.1 hypothetical protein -
LQV31_RS07445 (1498376) 1498376..1499947 - 1572 WP_032433383.1 AAA family ATPase -
LQV31_RS07450 (1500266) 1500266..1500514 + 249 WP_032433382.1 hypothetical protein -
LQV31_RS07455 (1500573) 1500573..1501091 + 519 WP_045326794.1 hypothetical protein -
LQV31_RS07460 (1501122) 1501122..1501613 + 492 WP_032433378.1 hypothetical protein -
LQV31_RS07465 (1501673) 1501673..1501876 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1483316..1524621 41305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296389 WP_032433387.1 NZ_OW970486:1496629-1497045 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296389 WP_001261276.1 NZ_OW970486:1496402-1496632 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References