Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834115..834772 Replicon chromosome
Accession NZ_OW970486
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQV31_RS04175 Protein ID WP_002916310.1
Coordinates 834362..834772 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQV31_RS04170 Protein ID WP_002916312.1
Coordinates 834115..834381 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV31_RS04145 (829271) 829271..830704 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LQV31_RS04150 (830823) 830823..831551 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQV31_RS04155 (831601) 831601..831912 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQV31_RS04160 (832076) 832076..832735 + 660 WP_002916317.1 hemolysin III family protein -
LQV31_RS04165 (832886) 832886..833869 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQV31_RS04170 (834115) 834115..834381 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQV31_RS04175 (834362) 834362..834772 + 411 WP_002916310.1 protein YgfX Toxin
LQV31_RS04180 (834779) 834779..835300 - 522 WP_004144730.1 flavodoxin FldB -
LQV31_RS04185 (835401) 835401..836297 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQV31_RS04190 (836320) 836320..837033 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV31_RS04195 (837039) 837039..838772 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296388 WP_002916310.1 NZ_OW970486:834362-834772 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296388 WP_002916312.1 NZ_OW970486:834115-834381 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References