Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 115072..115595 Replicon plasmid P1
Accession NZ_OW970479
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name ccdB Uniprot ID V5RNQ6
Locus tag LQV36_RS26550 Protein ID WP_015632464.1
Coordinates 115072..115377 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V5RQR8
Locus tag LQV36_RS26555 Protein ID WP_015632465.1
Coordinates 115377..115595 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV36_RS26505 (AI2764V1_5034) 110102..110530 - 429 WP_015632456.1 plasmid partitioning/stability family protein -
LQV36_RS26510 (AI2764V1_5035) 110523..111503 - 981 WP_015632457.1 plasmid segregation protein ParM -
LQV36_RS26515 (AI2764V1_5036) 111864..112046 + 183 WP_015632458.1 type II toxin-antitoxin system HicA family toxin -
LQV36_RS26520 (AI2764V1_5037) 112072..112515 + 444 WP_015632459.1 type II toxin-antitoxin system HicB family antitoxin -
LQV36_RS26525 112721..112843 - 123 Protein_120 transcriptional regulator -
LQV36_RS26530 (AI2764V1_5039) 112857..113084 - 228 WP_016162072.1 hypothetical protein -
LQV36_RS26535 113316..113771 + 456 WP_015632461.1 helix-turn-helix domain-containing protein -
LQV36_RS26540 114023..114118 - 96 Protein_123 IS1 family transposase -
LQV36_RS26545 (AI2764V1_5042) 114583..114960 - 378 WP_016162069.1 hypothetical protein -
LQV36_RS26550 (AI2764V1_5043) 115072..115377 - 306 WP_015632464.1 type II toxin-antitoxin system toxin CcdB Toxin
LQV36_RS26555 (AI2764V1_5044) 115377..115595 - 219 WP_015632465.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LQV36_RS26560 (AI2764V1_5045) 115781..116806 + 1026 WP_015632466.1 IS110 family transposase -
LQV36_RS26565 (AI2764V1_REPA000000037) 117101..117586 + 486 Protein_128 IS5 family transposase -
LQV36_RS26570 (AI2764V1_5046) 117750..118181 + 432 WP_015632467.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LQV36_RS26575 (AI2764V1_5047) 118181..119452 + 1272 WP_016162068.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtF / ARR-3 - 1..119845 119845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11361.90 Da        Isoelectric Point: 5.5252

>T296384 WP_015632464.1 NZ_OW970479:c115377-115072 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8194.13 Da        Isoelectric Point: 6.2224

>AT296384 WP_015632465.1 NZ_OW970479:c115595-115377 [Klebsiella pneumoniae]
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0ND19

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0L1T7

References