Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5229259..5229884 Replicon chromosome
Accession NZ_OW970478
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LQV36_RS25490 Protein ID WP_002882817.1
Coordinates 5229259..5229642 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LQV36_RS25495 Protein ID WP_004150355.1
Coordinates 5229642..5229884 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV36_RS25475 (5226625) 5226625..5227527 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LQV36_RS25480 (5227524) 5227524..5228159 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LQV36_RS25485 (5228156) 5228156..5229085 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQV36_RS25490 (5229259) 5229259..5229642 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV36_RS25495 (5229642) 5229642..5229884 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LQV36_RS25500 (5230089) 5230089..5231006 + 918 WP_021466676.1 alpha/beta hydrolase -
LQV36_RS25505 (5231020) 5231020..5231961 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LQV36_RS25510 (5232006) 5232006..5232443 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LQV36_RS25515 (5232440) 5232440..5233300 - 861 WP_004146232.1 virulence factor BrkB family protein -
LQV36_RS25520 (5233294) 5233294..5233893 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296383 WP_002882817.1 NZ_OW970478:c5229642-5229259 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT296383 WP_004150355.1 NZ_OW970478:c5229884-5229642 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References