Detailed information of TA system TA296382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4916976..4918657
• Replicon: chromosome
• Accession: NZ_OW970478
• Organism: Klebsiella pneumoniae isolate 147

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: LQV36_RS24030
• Protein ID: WP_015959269.1
• Coordinates: 4916976..4917851 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LQV36_RS24035
• Protein ID: WP_004177809.1
• Coordinates: 4917899..4918657 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQV36_RS24010 (4912282)	4912282..4913802	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LQV36_RS24015 (4913799)	4913799..4914797	+	999	WP_002885172.1	ribose ABC transporter permease	-
LQV36_RS24020 (4914828)	4914828..4915769	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LQV36_RS24025 (4915844)	4915844..4916851	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
LQV36_RS24030 (4916976)	4916976..4917851	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQV36_RS24035 (4917899)	4917899..4918657	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LQV36_RS24040 (4918743)	4918743..4919471	-	729	WP_032413197.1	response regulator transcription factor	-
LQV36_RS24045 (4919744)	4919744..4921891	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LQV36_RS24050 (4922050)	4922050..4923413	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T296382 WP_015959269.1 NZ_OW970478:c4917851-4916976 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296382 WP_004177809.1 NZ_OW970478:c4918657-4917899 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05