Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4757237..4757753 Replicon chromosome
Accession NZ_OW970478
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV36_RS23215 Protein ID WP_009486548.1
Coordinates 4757237..4757521 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV36_RS23220 Protein ID WP_002886901.1
Coordinates 4757511..4757753 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV36_RS23190 (4752654) 4752654..4752917 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV36_RS23195 (4753047) 4753047..4753220 + 174 WP_032433782.1 hypothetical protein -
LQV36_RS23200 (4753223) 4753223..4753966 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV36_RS23205 (4754323) 4754323..4756461 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV36_RS23210 (4756769) 4756769..4757233 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV36_RS23215 (4757237) 4757237..4757521 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV36_RS23220 (4757511) 4757511..4757753 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV36_RS23225 (4757831) 4757831..4759741 - 1911 WP_229976683.1 PRD domain-containing protein -
LQV36_RS23230 (4759764) 4759764..4760918 - 1155 WP_002886900.1 lactonase family protein -
LQV36_RS23235 (4760985) 4760985..4761725 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296381 WP_009486548.1 NZ_OW970478:c4757521-4757237 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296381 WP_002886901.1 NZ_OW970478:c4757753-4757511 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References