Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2756904..2758492 Replicon chromosome
Accession NZ_OW970478
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQV36_RS13600 Protein ID WP_002904792.1
Coordinates 2756904..2758226 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQV36_RS13605 Protein ID WP_002904790.1
Coordinates 2758226..2758492 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV36_RS13585 (2751960) 2751960..2754461 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQV36_RS13590 (2754449) 2754449..2755453 + 1005 WP_032433097.1 fimbrial protein -
LQV36_RS13595 (2755595) 2755595..2756887 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV36_RS13600 (2756904) 2756904..2758226 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV36_RS13605 (2758226) 2758226..2758492 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV36_RS13610 (2758878) 2758878..2759204 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQV36_RS13615 (2759201) 2759201..2759701 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV36_RS13620 (2759679) 2759679..2761058 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQV36_RS13625 (2761404) 2761404..2762558 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV36_RS13630 (2762539) 2762539..2763462 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296378 WP_002904792.1 NZ_OW970478:c2758226-2756904 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296378 WP_002904790.1 NZ_OW970478:c2758492-2758226 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References