Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1817..2460 Replicon plasmid P3
Accession NZ_OW970455
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID R9WRW3
Locus tag LQV13_RS26935 Protein ID WP_015063455.1
Coordinates 1817..2233 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV13_RS26940 Protein ID WP_001261276.1
Coordinates 2230..2460 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV13_RS26930 (AI2767V1_REPA000000097) 717..1573 - 857 Protein_1 IS3-like element ISEc15 family transposase -
LQV13_RS26935 (AI2767V1_5122) 1817..2233 - 417 WP_015063455.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV13_RS26940 (AI2767V1_5123) 2230..2460 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV13_RS26945 (AI2767V1_5124) 3034..3384 + 351 WP_000493378.1 hypothetical protein -
LQV13_RS26950 (AI2767V1_5125) 3435..4178 + 744 WP_000129823.1 hypothetical protein -
LQV13_RS26955 (AI2767V1_5126) 4175..4951 + 777 WP_000015958.1 site-specific integrase -
LQV13_RS26960 (AI2767V1_5127) 5009..5266 - 258 WP_000764642.1 hypothetical protein -
LQV13_RS26965 5395..5499 - 105 WP_032409716.1 hypothetical protein -
LQV13_RS26970 (AI2767V1_5128) 6034..6900 + 867 WP_004118283.1 replication initiation protein -
LQV13_RS26975 (AI2767V1_5129) 7077..7346 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 / ARR-3 / rmtF / mph(A) - 1..58021 58021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15036.50 Da        Isoelectric Point: 8.5440

>T296368 WP_015063455.1 NZ_OW970455:c2233-1817 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVN

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296368 WP_001261276.1 NZ_OW970455:c2460-2230 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9WRW3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References