Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1505101..1505837 Replicon chromosome
Accession NZ_OW970452
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV13_RS07500 Protein ID WP_032433360.1
Coordinates 1505355..1505837 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV13_RS07495 Protein ID WP_003026799.1
Coordinates 1505101..1505367 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV13_RS07470 (1500747) 1500747..1501886 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV13_RS07475 (1501915) 1501915..1502577 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV13_RS07480 (1502558) 1502558..1503565 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV13_RS07485 (1503583) 1503583..1504215 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV13_RS07490 (1504225) 1504225..1504788 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV13_RS07495 (1505101) 1505101..1505367 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV13_RS07500 (1505355) 1505355..1505837 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV13_RS07505 (1506037) 1506037..1507440 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV13_RS07510 (1507469) 1507469..1508101 - 633 WP_060591614.1 hypothetical protein -
LQV13_RS07515 (1508481) 1508481..1509080 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV13_RS07520 (1509293) 1509293..1510237 - 945 WP_077254249.1 fimbrial protein -
LQV13_RS07525 (1510249) 1510249..1510509 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1475324..1518912 43588
- flank IS/Tn - - 1506037..1507440 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296356 WP_032433360.1 NZ_OW970452:1505355-1505837 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296356 WP_003026799.1 NZ_OW970452:1505101-1505367 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References