Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1488410..1489053 Replicon chromosome
Accession NZ_OW970452
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV13_RS07405 Protein ID WP_032433387.1
Coordinates 1488637..1489053 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV13_RS07400 Protein ID WP_001261276.1
Coordinates 1488410..1488640 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV13_RS07385 (1483432) 1483432..1484519 + 1088 Protein_1445 transcriptional repressor PifC -
LQV13_RS07390 (1484522) 1484522..1486762 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV13_RS07395 (1487290) 1487290..1488105 - 816 WP_032433388.1 hypothetical protein -
LQV13_RS07400 (1488410) 1488410..1488640 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV13_RS07405 (1488637) 1488637..1489053 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV13_RS07410 (1489209) 1489209..1490189 + 981 WP_032433385.1 hypothetical protein -
LQV13_RS07415 (1490384) 1490384..1491955 - 1572 WP_032433383.1 AAA family ATPase -
LQV13_RS07420 (1492274) 1492274..1492522 + 249 WP_032433382.1 hypothetical protein -
LQV13_RS07425 (1492581) 1492581..1493099 + 519 WP_045326794.1 hypothetical protein -
LQV13_RS07430 (1493130) 1493130..1493621 + 492 WP_032433378.1 hypothetical protein -
LQV13_RS07435 (1493681) 1493681..1493884 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1475324..1518912 43588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296355 WP_032433387.1 NZ_OW970452:1488637-1489053 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296355 WP_001261276.1 NZ_OW970452:1488410-1488640 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References