Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795504..796161 Replicon chromosome
Accession NZ_OW970444
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQV08_RS03950 Protein ID WP_002916310.1
Coordinates 795751..796161 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQV08_RS03945 Protein ID WP_002916312.1
Coordinates 795504..795770 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV08_RS03920 (790660) 790660..792093 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
LQV08_RS03925 (792212) 792212..792940 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQV08_RS03930 (792990) 792990..793301 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQV08_RS03935 (793465) 793465..794124 + 660 WP_002916317.1 hemolysin III family protein -
LQV08_RS03940 (794275) 794275..795258 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQV08_RS03945 (795504) 795504..795770 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQV08_RS03950 (795751) 795751..796161 + 411 WP_002916310.1 protein YgfX Toxin
LQV08_RS03955 (796168) 796168..796689 - 522 WP_004144730.1 flavodoxin FldB -
LQV08_RS03960 (796790) 796790..797686 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQV08_RS03965 (797709) 797709..798422 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV08_RS03970 (798428) 798428..800161 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296338 WP_002916310.1 NZ_OW970444:795751-796161 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296338 WP_002916312.1 NZ_OW970444:795504-795770 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References