Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5242706..5243331 Replicon chromosome
Accession NZ_OW970436
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LQV41_RS25530 Protein ID WP_002882817.1
Coordinates 5242706..5243089 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LQV41_RS25535 Protein ID WP_004150355.1
Coordinates 5243089..5243331 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV41_RS25515 (5240072) 5240072..5240974 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LQV41_RS25520 (5240971) 5240971..5241606 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LQV41_RS25525 (5241603) 5241603..5242532 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQV41_RS25530 (5242706) 5242706..5243089 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV41_RS25535 (5243089) 5243089..5243331 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LQV41_RS25540 (5243536) 5243536..5244453 + 918 WP_021466676.1 alpha/beta hydrolase -
LQV41_RS25545 (5244467) 5244467..5245408 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LQV41_RS25550 (5245453) 5245453..5245890 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LQV41_RS25555 (5245887) 5245887..5246747 - 861 WP_004146232.1 virulence factor BrkB family protein -
LQV41_RS25560 (5246741) 5246741..5247340 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296334 WP_002882817.1 NZ_OW970436:c5243089-5242706 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT296334 WP_004150355.1 NZ_OW970436:c5243331-5243089 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References