Detailed information of TA system TA296333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4930423..4932104
• Replicon: chromosome
• Accession: NZ_OW970436
• Organism: Klebsiella pneumoniae isolate 147

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: LQV41_RS24070
• Protein ID: WP_015959269.1
• Coordinates: 4930423..4931298 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LQV41_RS24075
• Protein ID: WP_004177809.1
• Coordinates: 4931346..4932104 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQV41_RS24050 (4925729)	4925729..4927249	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LQV41_RS24055 (4927246)	4927246..4928244	+	999	WP_002885172.1	ribose ABC transporter permease	-
LQV41_RS24060 (4928275)	4928275..4929216	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LQV41_RS24065 (4929291)	4929291..4930298	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
LQV41_RS24070 (4930423)	4930423..4931298	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQV41_RS24075 (4931346)	4931346..4932104	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LQV41_RS24080 (4932190)	4932190..4932918	-	729	WP_032413197.1	response regulator transcription factor	-
LQV41_RS24085 (4933191)	4933191..4935338	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LQV41_RS24090 (4935497)	4935497..4936860	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T296333 WP_015959269.1 NZ_OW970436:c4931298-4930423 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296333 WP_004177809.1 NZ_OW970436:c4932104-4931346 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05