Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1514284..1515020 Replicon chromosome
Accession NZ_OW970436
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV41_RS07535 Protein ID WP_032433360.1
Coordinates 1514538..1515020 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV41_RS07530 Protein ID WP_003026799.1
Coordinates 1514284..1514550 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV41_RS07505 (1509930) 1509930..1511069 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV41_RS07510 (1511098) 1511098..1511760 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV41_RS07515 (1511741) 1511741..1512748 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV41_RS07520 (1512766) 1512766..1513398 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV41_RS07525 (1513408) 1513408..1513971 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV41_RS07530 (1514284) 1514284..1514550 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV41_RS07535 (1514538) 1514538..1515020 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV41_RS07540 (1515220) 1515220..1516623 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV41_RS07545 (1516652) 1516652..1517284 - 633 WP_060591614.1 hypothetical protein -
LQV41_RS07550 (1517664) 1517664..1518263 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV41_RS07555 (1518476) 1518476..1519420 - 945 WP_077254249.1 fimbrial protein -
LQV41_RS07560 (1519432) 1519432..1519692 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1484507..1528095 43588
- flank IS/Tn - - 1515220..1516623 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296324 WP_032433360.1 NZ_OW970436:1514538-1515020 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296324 WP_003026799.1 NZ_OW970436:1514284-1514550 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References