Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 116293..116816 Replicon plasmid P1
Accession NZ_OW970423
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name ccdB Uniprot ID V5RNQ6
Locus tag LQV34_RS26545 Protein ID WP_015632464.1
Coordinates 116293..116598 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V5RQR8
Locus tag LQV34_RS26550 Protein ID WP_015632465.1
Coordinates 116598..116816 (-) Length 73 a.a.

Genomic Context


LQV34_RS26510LQV34_RS26515LQV34_RS26530LQV34_RS26555LQV34_RS26560LQV34_RS26565LQV34_RS26570LQV34_RS26500LQV34_RS26505LQV34_RS26520LQV34_RS26525LQV34_RS26535LQV34_RS26540LQV34_RS26545LQV34_RS26550
Location: 113085..113267 (183 bp)
Type: Others
Protein ID: WP_015632458.1
Location: 113293..113736 (444 bp)
Type: Others
Protein ID: WP_015632459.1
Location: 114537..114992 (456 bp)
Type: Others
Protein ID: WP_015632461.1
Location: 117002..118027 (1026 bp)
Type: Others
Protein ID: WP_015632466.1
Location: 118322..118807 (486 bp)
Type: Others
Protein ID: Protein_128
Location: 118971..119402 (432 bp)
Type: Others
Protein ID: WP_015632467.1
Location: 119402..120673 (1272 bp)
Type: Others
Protein ID: WP_016162068.1
Location: 111323..111751 (429 bp)
Type: Others
Protein ID: WP_015632456.1
Location: 111744..112724 (981 bp)
Type: Others
Protein ID: WP_015632457.1
Location: 113942..114064 (123 bp)
Type: Others
Protein ID: Protein_120
Location: 114078..114305 (228 bp)
Type: Others
Protein ID: WP_016162072.1
Location: 115244..115339 (96 bp)
Type: Others
Protein ID: Protein_123
Location: 115804..116181 (378 bp)
Type: Others
Protein ID: WP_016162069.1
Location: 116293..116598 (306 bp)
Type: Toxin
Protein ID: WP_015632464.1
Location: 116598..116816 (219 bp)
Type: Antitoxin
Protein ID: WP_015632465.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LQV34_RS26500 (AI2770V1_5030)111323..111751-429WP_015632456.1plasmid partitioning/stability family protein-
LQV34_RS26505 (AI2770V1_5031)111744..112724-981WP_015632457.1plasmid segregation protein ParM-
LQV34_RS26510 (AI2770V1_5032)113085..113267+183WP_015632458.1type II toxin-antitoxin system HicA family toxin-
LQV34_RS26515 (AI2770V1_5033)113293..113736+444WP_015632459.1type II toxin-antitoxin system HicB family antitoxin-
LQV34_RS26520113942..114064-123Protein_120transcriptional regulator-
LQV34_RS26525 (AI2770V1_5035)114078..114305-228WP_016162072.1hypothetical protein-
LQV34_RS26530114537..114992+456WP_015632461.1helix-turn-helix domain-containing protein-
LQV34_RS26535115244..115339-96Protein_123IS1 family transposase-
LQV34_RS26540 (AI2770V1_5038)115804..116181-378WP_016162069.1hypothetical protein-
LQV34_RS26545 (AI2770V1_5039)116293..116598-306WP_015632464.1type II toxin-antitoxin system toxin CcdBToxin
LQV34_RS26550 (AI2770V1_5040)116598..116816-219WP_015632465.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
LQV34_RS26555 (AI2770V1_5041)117002..118027+1026WP_015632466.1IS110 family transposase-
LQV34_RS26560 (AI2770V1_REPA000000035)118322..118807+486Protein_128IS5 family transposase-
LQV34_RS26565 (AI2770V1_5042)118971..119402+432WP_015632467.1translesion error-prone DNA polymerase V autoproteolytic subunit-
LQV34_RS26570 (AI2770V1_5043)119402..120673+1272WP_016162068.1Y-family DNA polymerase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidrmtF / ARR-3-1..121066121066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11361.90 Da        Isoelectric Point: 5.5252

>T296319 WP_015632464.1 NZ_OW970423:c116598-116293 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI

Download         Length: 306 bp


Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8194.13 Da        Isoelectric Point: 6.2224

>AT296319 WP_015632465.1 NZ_OW970423:c116816-116598 [Klebsiella pneumoniae]
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW

Download         Length: 219 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A6C0ND19


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6C0L1T7

References