Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 116293..116816 | Replicon | plasmid P1 |
Accession | NZ_OW970423 | ||
Organism | Klebsiella pneumoniae isolate 147 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | V5RNQ6 |
Locus tag | LQV34_RS26545 | Protein ID | WP_015632464.1 |
Coordinates | 116293..116598 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V5RQR8 |
Locus tag | LQV34_RS26550 | Protein ID | WP_015632465.1 |
Coordinates | 116598..116816 (-) | Length | 73 a.a. |
Genomic Context
Location: 113085..113267 (183 bp)
Type: Others
Protein ID: WP_015632458.1
Type: Others
Protein ID: WP_015632458.1
Location: 113293..113736 (444 bp)
Type: Others
Protein ID: WP_015632459.1
Type: Others
Protein ID: WP_015632459.1
Location: 114537..114992 (456 bp)
Type: Others
Protein ID: WP_015632461.1
Type: Others
Protein ID: WP_015632461.1
Location: 117002..118027 (1026 bp)
Type: Others
Protein ID: WP_015632466.1
Type: Others
Protein ID: WP_015632466.1
Location: 118322..118807 (486 bp)
Type: Others
Protein ID: Protein_128
Type: Others
Protein ID: Protein_128
Location: 118971..119402 (432 bp)
Type: Others
Protein ID: WP_015632467.1
Type: Others
Protein ID: WP_015632467.1
Location: 119402..120673 (1272 bp)
Type: Others
Protein ID: WP_016162068.1
Type: Others
Protein ID: WP_016162068.1
Location: 111323..111751 (429 bp)
Type: Others
Protein ID: WP_015632456.1
Type: Others
Protein ID: WP_015632456.1
Location: 111744..112724 (981 bp)
Type: Others
Protein ID: WP_015632457.1
Type: Others
Protein ID: WP_015632457.1
Location: 113942..114064 (123 bp)
Type: Others
Protein ID: Protein_120
Type: Others
Protein ID: Protein_120
Location: 114078..114305 (228 bp)
Type: Others
Protein ID: WP_016162072.1
Type: Others
Protein ID: WP_016162072.1
Location: 115244..115339 (96 bp)
Type: Others
Protein ID: Protein_123
Type: Others
Protein ID: Protein_123
Location: 115804..116181 (378 bp)
Type: Others
Protein ID: WP_016162069.1
Type: Others
Protein ID: WP_016162069.1
Location: 116293..116598 (306 bp)
Type: Toxin
Protein ID: WP_015632464.1
Type: Toxin
Protein ID: WP_015632464.1
Location: 116598..116816 (219 bp)
Type: Antitoxin
Protein ID: WP_015632465.1
Type: Antitoxin
Protein ID: WP_015632465.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQV34_RS26500 (AI2770V1_5030) | 111323..111751 | - | 429 | WP_015632456.1 | plasmid partitioning/stability family protein | - |
LQV34_RS26505 (AI2770V1_5031) | 111744..112724 | - | 981 | WP_015632457.1 | plasmid segregation protein ParM | - |
LQV34_RS26510 (AI2770V1_5032) | 113085..113267 | + | 183 | WP_015632458.1 | type II toxin-antitoxin system HicA family toxin | - |
LQV34_RS26515 (AI2770V1_5033) | 113293..113736 | + | 444 | WP_015632459.1 | type II toxin-antitoxin system HicB family antitoxin | - |
LQV34_RS26520 | 113942..114064 | - | 123 | Protein_120 | transcriptional regulator | - |
LQV34_RS26525 (AI2770V1_5035) | 114078..114305 | - | 228 | WP_016162072.1 | hypothetical protein | - |
LQV34_RS26530 | 114537..114992 | + | 456 | WP_015632461.1 | helix-turn-helix domain-containing protein | - |
LQV34_RS26535 | 115244..115339 | - | 96 | Protein_123 | IS1 family transposase | - |
LQV34_RS26540 (AI2770V1_5038) | 115804..116181 | - | 378 | WP_016162069.1 | hypothetical protein | - |
LQV34_RS26545 (AI2770V1_5039) | 116293..116598 | - | 306 | WP_015632464.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
LQV34_RS26550 (AI2770V1_5040) | 116598..116816 | - | 219 | WP_015632465.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
LQV34_RS26555 (AI2770V1_5041) | 117002..118027 | + | 1026 | WP_015632466.1 | IS110 family transposase | - |
LQV34_RS26560 (AI2770V1_REPA000000035) | 118322..118807 | + | 486 | Protein_128 | IS5 family transposase | - |
LQV34_RS26565 (AI2770V1_5042) | 118971..119402 | + | 432 | WP_015632467.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
LQV34_RS26570 (AI2770V1_5043) | 119402..120673 | + | 1272 | WP_016162068.1 | Y-family DNA polymerase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | rmtF / ARR-3 | - | 1..121066 | 121066 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11361.90 Da Isoelectric Point: 5.5252
>T296319 WP_015632464.1 NZ_OW970423:c116598-116293 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
Download Length: 306 bp
Antitoxin
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C0ND19 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C0L1T7 |