Detailed information of TA system TA296317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4911364..4913045
• Replicon: chromosome
• Accession: NZ_OW970422
• Organism: Klebsiella pneumoniae isolate 147

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: LQV34_RS24025
• Protein ID: WP_015959269.1
• Coordinates: 4911364..4912239 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LQV34_RS24030
• Protein ID: WP_004177809.1
• Coordinates: 4912287..4913045 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQV34_RS24005 (4906670)	4906670..4908190	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LQV34_RS24010 (4908187)	4908187..4909185	+	999	WP_002885172.1	ribose ABC transporter permease	-
LQV34_RS24015 (4909216)	4909216..4910157	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LQV34_RS24020 (4910232)	4910232..4911239	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
LQV34_RS24025 (4911364)	4911364..4912239	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQV34_RS24030 (4912287)	4912287..4913045	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LQV34_RS24035 (4913131)	4913131..4913859	-	729	WP_032413197.1	response regulator transcription factor	-
LQV34_RS24040 (4914132)	4914132..4916279	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LQV34_RS24045 (4916438)	4916438..4917801	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T296317 WP_015959269.1 NZ_OW970422:c4912239-4911364 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296317 WP_004177809.1 NZ_OW970422:c4913045-4912287 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05