Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4751625..4752141 Replicon chromosome
Accession NZ_OW970422
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV34_RS23210 Protein ID WP_009486548.1
Coordinates 4751625..4751909 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV34_RS23215 Protein ID WP_002886901.1
Coordinates 4751899..4752141 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV34_RS23185 (4747042) 4747042..4747305 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV34_RS23190 (4747435) 4747435..4747608 + 174 WP_032433782.1 hypothetical protein -
LQV34_RS23195 (4747611) 4747611..4748354 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV34_RS23200 (4748711) 4748711..4750849 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV34_RS23205 (4751157) 4751157..4751621 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV34_RS23210 (4751625) 4751625..4751909 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV34_RS23215 (4751899) 4751899..4752141 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV34_RS23220 (4752219) 4752219..4754129 - 1911 WP_009486549.1 PRD domain-containing protein -
LQV34_RS23225 (4754152) 4754152..4755306 - 1155 WP_002886900.1 lactonase family protein -
LQV34_RS23230 (4755373) 4755373..4756113 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296316 WP_009486548.1 NZ_OW970422:c4751909-4751625 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296316 WP_002886901.1 NZ_OW970422:c4752141-4751899 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References