Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2763140..2764728 Replicon chromosome
Accession NZ_OW970422
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQV34_RS13635 Protein ID WP_002904792.1
Coordinates 2763140..2764462 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQV34_RS13640 Protein ID WP_002904790.1
Coordinates 2764462..2764728 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV34_RS13620 (2758196) 2758196..2760697 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQV34_RS13625 (2760685) 2760685..2761689 + 1005 WP_032433097.1 fimbrial protein -
LQV34_RS13630 (2761831) 2761831..2763123 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV34_RS13635 (2763140) 2763140..2764462 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV34_RS13640 (2764462) 2764462..2764728 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV34_RS13645 (2765114) 2765114..2765440 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQV34_RS13650 (2765437) 2765437..2765937 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV34_RS13655 (2765915) 2765915..2767294 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQV34_RS13660 (2767640) 2767640..2768794 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV34_RS13665 (2768775) 2768775..2769698 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296313 WP_002904792.1 NZ_OW970422:c2764462-2763140 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296313 WP_002904790.1 NZ_OW970422:c2764728-2764462 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References