Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1513979..1514715 Replicon chromosome
Accession NZ_OW970422
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV34_RS07550 Protein ID WP_032433360.1
Coordinates 1514233..1514715 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV34_RS07545 Protein ID WP_003026799.1
Coordinates 1513979..1514245 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV34_RS07520 (1509625) 1509625..1510764 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV34_RS07525 (1510793) 1510793..1511455 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV34_RS07530 (1511436) 1511436..1512443 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV34_RS07535 (1512461) 1512461..1513093 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV34_RS07540 (1513103) 1513103..1513666 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV34_RS07545 (1513979) 1513979..1514245 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV34_RS07550 (1514233) 1514233..1514715 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV34_RS07555 (1515076) 1515076..1515675 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV34_RS07560 (1515888) 1515888..1516832 - 945 WP_077254249.1 fimbrial protein -
LQV34_RS07565 (1516844) 1516844..1517104 - 261 WP_035588053.1 hypothetical protein -
LQV34_RS07570 (1517275) 1517275..1518015 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1483425..1525507 42082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296308 WP_032433360.1 NZ_OW970422:1514233-1514715 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296308 WP_003026799.1 NZ_OW970422:1513979-1514245 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References