Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 7248..7891 Replicon plasmid P2
Accession NZ_OW970415
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID R9WRW3
Locus tag LQV26_RS26425 Protein ID WP_015063455.1
Coordinates 7248..7664 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV26_RS26430 Protein ID WP_001261276.1
Coordinates 7661..7891 (-) Length 77 a.a.

Genomic Context


LQV26_RS26405LQV26_RS26435LQV26_RS26440LQV26_RS26445LQV26_RS26460LQV26_RS26410LQV26_RS26415LQV26_RS26420LQV26_RS26425LQV26_RS26430LQV26_RS26450LQV26_RS26455LQV26_RS26465
Location: 2636..4192 (1557 bp)
Type: Others
Protein ID: WP_053897648.1
Location: 8465..8815 (351 bp)
Type: Others
Protein ID: WP_000493378.1
Location: 8866..9609 (744 bp)
Type: Others
Protein ID: WP_000129823.1
Location: 9606..10382 (777 bp)
Type: Others
Protein ID: WP_000015958.1
Location: 11465..12331 (867 bp)
Type: Others
Protein ID: WP_004118283.1
Location: 4495..4773 (279 bp)
Type: Others
Protein ID: Protein_4
Location: 4790..5866 (1077 bp)
Type: Others
Protein ID: WP_000227969.1
Location: 6148..7004 (857 bp)
Type: Others
Protein ID: Protein_6
Location: 7248..7664 (417 bp)
Type: Toxin
Protein ID: WP_015063455.1
Location: 7661..7891 (231 bp)
Type: Antitoxin
Protein ID: WP_001261276.1
Location: 10440..10697 (258 bp)
Type: Others
Protein ID: WP_000764642.1
Location: 10826..10930 (105 bp)
Type: Others
Protein ID: WP_032409716.1
Location: 12508..12777 (270 bp)
Type: Others
Protein ID: WP_000339857.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LQV26_RS26405 (AI2998V1_5017)2636..4192+1557WP_053897648.1PAS domain-containing methyl-accepting chemotaxis protein-
LQV26_RS26410 (AI2998V1_REPA000000102)4495..4773-279Protein_4IS3 family transposase-
LQV26_RS26415 (AI2998V1_5019)4790..5866-1077WP_000227969.1IS110 family transposase-
LQV26_RS26420 (AI2998V1_REPA000000104)6148..7004-857Protein_6IS3-like element ISEc15 family transposase-
LQV26_RS26425 (AI2998V1_5022)7248..7664-417WP_015063455.1type II toxin-antitoxin system VapC family toxinToxin
LQV26_RS26430 (AI2998V1_5023)7661..7891-231WP_001261276.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LQV26_RS26435 (AI2998V1_5024)8465..8815+351WP_000493378.1hypothetical protein-
LQV26_RS26440 (AI2998V1_5025)8866..9609+744WP_000129823.1hypothetical protein-
LQV26_RS26445 (AI2998V1_5026)9606..10382+777WP_000015958.1site-specific integrase-
LQV26_RS26450 (AI2998V1_5027)10440..10697-258WP_000764642.1hypothetical protein-
LQV26_RS2645510826..10930-105WP_032409716.1hypothetical protein-
LQV26_RS26460 (AI2998V1_5028)11465..12331+867WP_004118283.1replication initiation protein-
LQV26_RS26465 (AI2998V1_5029)12508..12777-270WP_000339857.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidmph(A) / blaCTX-M-15 / ARR-3 / rmtF / dfrA14 / qnrB1 / aph(3')-Ia / dfrA12 / qacE / sul1-1..8397583975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15036.50 Da        Isoelectric Point: 8.5440

>T296303 WP_015063455.1 NZ_OW970415:c7664-7248 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVN

Download         Length: 417 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296303 WP_001261276.1 NZ_OW970415:c7891-7661 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBR9WRW3


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A387K023

References