Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 7248..7891 | Replicon | plasmid P2 |
Accession | NZ_OW970415 | ||
Organism | Klebsiella pneumoniae isolate 147 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | R9WRW3 |
Locus tag | LQV26_RS26425 | Protein ID | WP_015063455.1 |
Coordinates | 7248..7664 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q84A07 |
Locus tag | LQV26_RS26430 | Protein ID | WP_001261276.1 |
Coordinates | 7661..7891 (-) | Length | 77 a.a. |
Genomic Context
Location: 2636..4192 (1557 bp)
Type: Others
Protein ID: WP_053897648.1
Type: Others
Protein ID: WP_053897648.1
Location: 8465..8815 (351 bp)
Type: Others
Protein ID: WP_000493378.1
Type: Others
Protein ID: WP_000493378.1
Location: 8866..9609 (744 bp)
Type: Others
Protein ID: WP_000129823.1
Type: Others
Protein ID: WP_000129823.1
Location: 9606..10382 (777 bp)
Type: Others
Protein ID: WP_000015958.1
Type: Others
Protein ID: WP_000015958.1
Location: 11465..12331 (867 bp)
Type: Others
Protein ID: WP_004118283.1
Type: Others
Protein ID: WP_004118283.1
Location: 4495..4773 (279 bp)
Type: Others
Protein ID: Protein_4
Type: Others
Protein ID: Protein_4
Location: 4790..5866 (1077 bp)
Type: Others
Protein ID: WP_000227969.1
Type: Others
Protein ID: WP_000227969.1
Location: 6148..7004 (857 bp)
Type: Others
Protein ID: Protein_6
Type: Others
Protein ID: Protein_6
Location: 7248..7664 (417 bp)
Type: Toxin
Protein ID: WP_015063455.1
Type: Toxin
Protein ID: WP_015063455.1
Location: 7661..7891 (231 bp)
Type: Antitoxin
Protein ID: WP_001261276.1
Type: Antitoxin
Protein ID: WP_001261276.1
Location: 10440..10697 (258 bp)
Type: Others
Protein ID: WP_000764642.1
Type: Others
Protein ID: WP_000764642.1
Location: 10826..10930 (105 bp)
Type: Others
Protein ID: WP_032409716.1
Type: Others
Protein ID: WP_032409716.1
Location: 12508..12777 (270 bp)
Type: Others
Protein ID: WP_000339857.1
Type: Others
Protein ID: WP_000339857.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQV26_RS26405 (AI2998V1_5017) | 2636..4192 | + | 1557 | WP_053897648.1 | PAS domain-containing methyl-accepting chemotaxis protein | - |
LQV26_RS26410 (AI2998V1_REPA000000102) | 4495..4773 | - | 279 | Protein_4 | IS3 family transposase | - |
LQV26_RS26415 (AI2998V1_5019) | 4790..5866 | - | 1077 | WP_000227969.1 | IS110 family transposase | - |
LQV26_RS26420 (AI2998V1_REPA000000104) | 6148..7004 | - | 857 | Protein_6 | IS3-like element ISEc15 family transposase | - |
LQV26_RS26425 (AI2998V1_5022) | 7248..7664 | - | 417 | WP_015063455.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LQV26_RS26430 (AI2998V1_5023) | 7661..7891 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LQV26_RS26435 (AI2998V1_5024) | 8465..8815 | + | 351 | WP_000493378.1 | hypothetical protein | - |
LQV26_RS26440 (AI2998V1_5025) | 8866..9609 | + | 744 | WP_000129823.1 | hypothetical protein | - |
LQV26_RS26445 (AI2998V1_5026) | 9606..10382 | + | 777 | WP_000015958.1 | site-specific integrase | - |
LQV26_RS26450 (AI2998V1_5027) | 10440..10697 | - | 258 | WP_000764642.1 | hypothetical protein | - |
LQV26_RS26455 | 10826..10930 | - | 105 | WP_032409716.1 | hypothetical protein | - |
LQV26_RS26460 (AI2998V1_5028) | 11465..12331 | + | 867 | WP_004118283.1 | replication initiation protein | - |
LQV26_RS26465 (AI2998V1_5029) | 12508..12777 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mph(A) / blaCTX-M-15 / ARR-3 / rmtF / dfrA14 / qnrB1 / aph(3')-Ia / dfrA12 / qacE / sul1 | - | 1..83975 | 83975 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15036.50 Da Isoelectric Point: 8.5440
>T296303 WP_015063455.1 NZ_OW970415:c7664-7248 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVN
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVN
Download Length: 417 bp
Antitoxin
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | R9WRW3 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A387K023 |