Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4655129..4655939 Replicon chromosome
Accession NZ_OW970413
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LQV26_RS22720 Protein ID WP_002887280.1
Coordinates 4655129..4655662 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LQV26_RS22725 Protein ID WP_002887278.1
Coordinates 4655673..4655939 (-) Length 89 a.a.

Genomic Context


LQV26_RS22715LQV26_RS22740LQV26_RS22745LQV26_RS22720LQV26_RS22725LQV26_RS22730LQV26_RS22735
Location: 4653961..4655082 (1122 bp)
Type: Others
Protein ID: WP_009309849.1
Location: 4658321..4659706 (1386 bp)
Type: Others
Protein ID: WP_032431458.1
Location: 4659724..4660029 (306 bp)
Type: Others
Protein ID: WP_032432083.1
Location: 4655129..4655662 (534 bp)
Type: Toxin
Protein ID: WP_002887280.1
Location: 4655673..4655939 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 4656042..4657475 (1434 bp)
Type: Others
Protein ID: WP_023288193.1
Location: 4657465..4658148 (684 bp)
Type: Others
Protein ID: WP_032105399.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LQV26_RS22715 (4653961)4653961..4655082+1122WP_009309849.1cupin domain-containing protein-
LQV26_RS22720 (4655129)4655129..4655662-534WP_002887280.1type II toxin-antitoxin system toxin KacTToxin
LQV26_RS22725 (4655673)4655673..4655939-267WP_002887278.1type II toxin-antitoxin system antitoxin KacAAntitoxin
LQV26_RS22730 (4656042)4656042..4657475-1434WP_023288193.1Cu(+)/Ag(+) sensor histidine kinase-
LQV26_RS22735 (4657465)4657465..4658148-684WP_032105399.1copper response regulator transcription factor CusR-
LQV26_RS22740 (4658321)4658321..4659706+1386WP_032431458.1efflux transporter outer membrane subunit-
LQV26_RS22745 (4659724)4659724..4660029+306WP_032432083.1cation efflux system protein CusF-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T296299 WP_002887280.1 NZ_OW970413:c4655662-4655129 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296299 WP_002887278.1 NZ_OW970413:c4655939-4655673 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB5ZGN
PDB5XUN


Antitoxin

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Source
ID
Structure
PDB5ZGN
AlphaFold DBA0A0H3GLZ1

References