Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2768475..2770063 Replicon chromosome
Accession NZ_OW970413
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQV26_RS13665 Protein ID WP_002904792.1
Coordinates 2768475..2769797 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQV26_RS13670 Protein ID WP_002904790.1
Coordinates 2769797..2770063 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV26_RS13650 (2763531) 2763531..2766032 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQV26_RS13655 (2766020) 2766020..2767024 + 1005 WP_032433097.1 fimbrial protein -
LQV26_RS13660 (2767166) 2767166..2768458 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV26_RS13665 (2768475) 2768475..2769797 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV26_RS13670 (2769797) 2769797..2770063 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV26_RS13675 (2770449) 2770449..2770775 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQV26_RS13680 (2770772) 2770772..2771272 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV26_RS13685 (2771250) 2771250..2772629 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQV26_RS13690 (2772975) 2772975..2774129 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV26_RS13695 (2774110) 2774110..2775033 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296297 WP_002904792.1 NZ_OW970413:c2769797-2768475 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296297 WP_002904790.1 NZ_OW970413:c2770063-2769797 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References