Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1514769..1515505 Replicon chromosome
Accession NZ_OW970413
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV26_RS07560 Protein ID WP_032433360.1
Coordinates 1515023..1515505 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV26_RS07555 Protein ID WP_003026799.1
Coordinates 1514769..1515035 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV26_RS07530 (1510415) 1510415..1511554 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV26_RS07535 (1511583) 1511583..1512245 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV26_RS07540 (1512226) 1512226..1513233 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV26_RS07545 (1513251) 1513251..1513883 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV26_RS07550 (1513893) 1513893..1514456 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV26_RS07555 (1514769) 1514769..1515035 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV26_RS07560 (1515023) 1515023..1515505 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV26_RS07565 (1515705) 1515705..1517108 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV26_RS07570 (1517137) 1517137..1517769 - 633 WP_060591614.1 hypothetical protein -
LQV26_RS07575 (1518149) 1518149..1518748 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV26_RS07580 (1518961) 1518961..1519905 - 945 WP_077254249.1 fimbrial protein -
LQV26_RS07585 (1519917) 1519917..1520177 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1483438..1528580 45142
- flank IS/Tn - - 1515705..1517108 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296292 WP_032433360.1 NZ_OW970413:1515023-1515505 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296292 WP_003026799.1 NZ_OW970413:1514769-1515035 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References