Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796281..796938 Replicon chromosome
Accession NZ_OW970374
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQV21_RS03955 Protein ID WP_002916310.1
Coordinates 796528..796938 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQV21_RS03950 Protein ID WP_002916312.1
Coordinates 796281..796547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV21_RS03925 (791437) 791437..792870 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
LQV21_RS03930 (792989) 792989..793717 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQV21_RS03935 (793767) 793767..794078 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQV21_RS03940 (794242) 794242..794901 + 660 WP_002916317.1 hemolysin III family protein -
LQV21_RS03945 (795052) 795052..796035 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQV21_RS03950 (796281) 796281..796547 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQV21_RS03955 (796528) 796528..796938 + 411 WP_002916310.1 protein YgfX Toxin
LQV21_RS03960 (796945) 796945..797466 - 522 WP_004144730.1 flavodoxin FldB -
LQV21_RS03965 (797567) 797567..798463 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQV21_RS03970 (798486) 798486..799199 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV21_RS03975 (799205) 799205..800938 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296274 WP_002916310.1 NZ_OW970374:796528-796938 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296274 WP_002916312.1 NZ_OW970374:796281-796547 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References