Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 112669..113192 Replicon plasmid P1
Accession NZ_OW970366
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name ccdB Uniprot ID V5RNQ6
Locus tag LQV23_RS26605 Protein ID WP_015632464.1
Coordinates 112669..112974 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V5RQR8
Locus tag LQV23_RS26610 Protein ID WP_015632465.1
Coordinates 112974..113192 (-) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV23_RS26560 (AI3000V1_5039) 107699..108127 - 429 WP_015632456.1 plasmid partitioning/stability family protein -
LQV23_RS26565 (AI3000V1_5040) 108120..109100 - 981 WP_015632457.1 plasmid segregation protein ParM -
LQV23_RS26570 (AI3000V1_5041) 109461..109643 + 183 WP_015632458.1 type II toxin-antitoxin system HicA family toxin -
LQV23_RS26575 (AI3000V1_5042) 109669..110112 + 444 WP_015632459.1 type II toxin-antitoxin system HicB family antitoxin -
LQV23_RS26580 110318..110440 - 123 Protein_119 transcriptional regulator -
LQV23_RS26585 (AI3000V1_5044) 110454..110681 - 228 WP_016162072.1 hypothetical protein -
LQV23_RS26590 110913..111368 + 456 WP_015632461.1 helix-turn-helix domain-containing protein -
LQV23_RS26595 111620..111715 - 96 Protein_122 IS1 family transposase -
LQV23_RS26600 (AI3000V1_5047) 112180..112557 - 378 WP_016162069.1 hypothetical protein -
LQV23_RS26605 (AI3000V1_5048) 112669..112974 - 306 WP_015632464.1 type II toxin-antitoxin system toxin CcdB Toxin
LQV23_RS26610 (AI3000V1_5049) 112974..113192 - 219 WP_015632465.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LQV23_RS26615 (AI3000V1_5050) 113378..114403 + 1026 WP_015632466.1 IS110 family transposase -
LQV23_RS26620 (AI3000V1_REPA000000038) 114698..115183 + 486 Protein_127 IS5 family transposase -
LQV23_RS26625 (AI3000V1_5051) 115347..115778 + 432 WP_117102862.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LQV23_RS26630 (AI3000V1_5052) 115778..117049 + 1272 WP_016162068.1 Y-family DNA polymerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtF / ARR-3 - 1..117442 117442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11361.90 Da        Isoelectric Point: 5.5252

>T296271 WP_015632464.1 NZ_OW970366:c112974-112669 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI

Download         Length: 306 bp


Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8194.13 Da        Isoelectric Point: 6.2224

>AT296271 WP_015632465.1 NZ_OW970366:c113192-112974 [Klebsiella pneumoniae]
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW

Download         Length: 219 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6C0ND19


Antitoxin

Source ID Structure
AlphaFold DB A0A6C0L1T7

References