Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 112669..113192 | Replicon | plasmid P1 |
Accession | NZ_OW970366 | ||
Organism | Klebsiella pneumoniae isolate 147 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | V5RNQ6 |
Locus tag | LQV23_RS26605 | Protein ID | WP_015632464.1 |
Coordinates | 112669..112974 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V5RQR8 |
Locus tag | LQV23_RS26610 | Protein ID | WP_015632465.1 |
Coordinates | 112974..113192 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQV23_RS26560 (AI3000V1_5039) | 107699..108127 | - | 429 | WP_015632456.1 | plasmid partitioning/stability family protein | - |
LQV23_RS26565 (AI3000V1_5040) | 108120..109100 | - | 981 | WP_015632457.1 | plasmid segregation protein ParM | - |
LQV23_RS26570 (AI3000V1_5041) | 109461..109643 | + | 183 | WP_015632458.1 | type II toxin-antitoxin system HicA family toxin | - |
LQV23_RS26575 (AI3000V1_5042) | 109669..110112 | + | 444 | WP_015632459.1 | type II toxin-antitoxin system HicB family antitoxin | - |
LQV23_RS26580 | 110318..110440 | - | 123 | Protein_119 | transcriptional regulator | - |
LQV23_RS26585 (AI3000V1_5044) | 110454..110681 | - | 228 | WP_016162072.1 | hypothetical protein | - |
LQV23_RS26590 | 110913..111368 | + | 456 | WP_015632461.1 | helix-turn-helix domain-containing protein | - |
LQV23_RS26595 | 111620..111715 | - | 96 | Protein_122 | IS1 family transposase | - |
LQV23_RS26600 (AI3000V1_5047) | 112180..112557 | - | 378 | WP_016162069.1 | hypothetical protein | - |
LQV23_RS26605 (AI3000V1_5048) | 112669..112974 | - | 306 | WP_015632464.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
LQV23_RS26610 (AI3000V1_5049) | 112974..113192 | - | 219 | WP_015632465.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
LQV23_RS26615 (AI3000V1_5050) | 113378..114403 | + | 1026 | WP_015632466.1 | IS110 family transposase | - |
LQV23_RS26620 (AI3000V1_REPA000000038) | 114698..115183 | + | 486 | Protein_127 | IS5 family transposase | - |
LQV23_RS26625 (AI3000V1_5051) | 115347..115778 | + | 432 | WP_117102862.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
LQV23_RS26630 (AI3000V1_5052) | 115778..117049 | + | 1272 | WP_016162068.1 | Y-family DNA polymerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | rmtF / ARR-3 | - | 1..117442 | 117442 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11361.90 Da Isoelectric Point: 5.5252
>T296271 WP_015632464.1 NZ_OW970366:c112974-112669 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
Download Length: 306 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C0ND19 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C0L1T7 |