Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4771598..4772114 Replicon chromosome
Accession NZ_OW970365
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV23_RS23275 Protein ID WP_009486548.1
Coordinates 4771598..4771882 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV23_RS23280 Protein ID WP_002886901.1
Coordinates 4771872..4772114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV23_RS23250 (4767015) 4767015..4767278 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV23_RS23255 (4767408) 4767408..4767581 + 174 WP_032433782.1 hypothetical protein -
LQV23_RS23260 (4767584) 4767584..4768327 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV23_RS23265 (4768684) 4768684..4770822 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV23_RS23270 (4771130) 4771130..4771594 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV23_RS23275 (4771598) 4771598..4771882 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV23_RS23280 (4771872) 4771872..4772114 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV23_RS23285 (4772192) 4772192..4774102 - 1911 WP_009486549.1 PRD domain-containing protein -
LQV23_RS23290 (4774125) 4774125..4775279 - 1155 WP_002886900.1 lactonase family protein -
LQV23_RS23295 (4775346) 4775346..4776086 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296268 WP_009486548.1 NZ_OW970365:c4771882-4771598 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296268 WP_002886901.1 NZ_OW970365:c4772114-4771872 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References