Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4667797..4668607 Replicon chromosome
Accession NZ_OW970365
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LQV23_RS22745 Protein ID WP_002887280.1
Coordinates 4667797..4668330 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LQV23_RS22750 Protein ID WP_002887278.1
Coordinates 4668341..4668607 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV23_RS22740 (4666629) 4666629..4667750 + 1122 WP_009309849.1 cupin domain-containing protein -
LQV23_RS22745 (4667797) 4667797..4668330 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
LQV23_RS22750 (4668341) 4668341..4668607 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LQV23_RS22755 (4668710) 4668710..4670143 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
LQV23_RS22760 (4670133) 4670133..4670816 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
LQV23_RS22765 (4670989) 4670989..4672374 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
LQV23_RS22770 (4672392) 4672392..4672697 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T296267 WP_002887280.1 NZ_OW970365:c4668330-4667797 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296267 WP_002887278.1 NZ_OW970365:c4668607-4668341 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References