Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1513812..1514548 Replicon chromosome
Accession NZ_OW970365
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV23_RS07540 Protein ID WP_032433360.1
Coordinates 1514066..1514548 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV23_RS07535 Protein ID WP_003026799.1
Coordinates 1513812..1514078 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV23_RS07510 (1509458) 1509458..1510597 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV23_RS07515 (1510626) 1510626..1511288 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV23_RS07520 (1511269) 1511269..1512276 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV23_RS07525 (1512294) 1512294..1512926 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV23_RS07530 (1512936) 1512936..1513499 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV23_RS07535 (1513812) 1513812..1514078 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV23_RS07540 (1514066) 1514066..1514548 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV23_RS07545 (1514748) 1514748..1516151 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV23_RS07550 (1516180) 1516180..1516812 - 633 WP_060591614.1 hypothetical protein -
LQV23_RS07555 (1517192) 1517192..1517791 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV23_RS07560 (1518004) 1518004..1518948 - 945 WP_077254249.1 fimbrial protein -
LQV23_RS07565 (1518960) 1518960..1519220 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1484035..1527623 43588
- flank IS/Tn - - 1514748..1516151 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296260 WP_032433360.1 NZ_OW970365:1514066-1514548 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296260 WP_003026799.1 NZ_OW970365:1513812-1514078 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References