Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835489..836146 Replicon chromosome
Accession NZ_OW970365
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQV23_RS04185 Protein ID WP_002916310.1
Coordinates 835736..836146 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQV23_RS04180 Protein ID WP_002916312.1
Coordinates 835489..835755 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV23_RS04155 (830645) 830645..832078 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LQV23_RS04160 (832197) 832197..832925 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LQV23_RS04165 (832975) 832975..833286 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LQV23_RS04170 (833450) 833450..834109 + 660 WP_002916317.1 hemolysin III family protein -
LQV23_RS04175 (834260) 834260..835243 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LQV23_RS04180 (835489) 835489..835755 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQV23_RS04185 (835736) 835736..836146 + 411 WP_002916310.1 protein YgfX Toxin
LQV23_RS04190 (836153) 836153..836674 - 522 WP_004144730.1 flavodoxin FldB -
LQV23_RS04195 (836775) 836775..837671 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LQV23_RS04200 (837694) 837694..838407 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV23_RS04205 (838413) 838413..840146 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296258 WP_002916310.1 NZ_OW970365:835736-836146 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296258 WP_002916312.1 NZ_OW970365:835489-835755 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References