Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4036914..4037533 Replicon chromosome
Accession NZ_OW970357
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQV29_RS19725 Protein ID WP_002892050.1
Coordinates 4037315..4037533 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LQV29_RS19720 Protein ID WP_002892066.1
Coordinates 4036914..4037288 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV29_RS19710 (4032066) 4032066..4033259 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQV29_RS19715 (4033282) 4033282..4036428 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LQV29_RS19720 (4036914) 4036914..4037288 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LQV29_RS19725 (4037315) 4037315..4037533 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQV29_RS19730 (4037696) 4037696..4038262 + 567 WP_002892030.1 maltose O-acetyltransferase -
LQV29_RS19735 (4038234) 4038234..4038374 - 141 WP_004147370.1 hypothetical protein -
LQV29_RS19740 (4038395) 4038395..4038865 + 471 WP_020802585.1 YlaC family protein -
LQV29_RS19745 (4038840) 4038840..4040291 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
LQV29_RS19750 (4040392) 4040392..4041090 + 699 WP_023287311.1 GNAT family protein -
LQV29_RS19755 (4041087) 4041087..4041227 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LQV29_RS19760 (4041227) 4041227..4041490 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296249 WP_002892050.1 NZ_OW970357:4037315-4037533 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT296249 WP_002892066.1 NZ_OW970357:4036914-4037288 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References