Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1497121..1497764 Replicon chromosome
Accession NZ_OW970357
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV29_RS07445 Protein ID WP_032433387.1
Coordinates 1497348..1497764 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV29_RS07440 Protein ID WP_001261276.1
Coordinates 1497121..1497351 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV29_RS07425 (1492143) 1492143..1493230 + 1088 Protein_1453 transcriptional repressor PifC -
LQV29_RS07430 (1493233) 1493233..1495473 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV29_RS07435 (1496001) 1496001..1496816 - 816 WP_032433388.1 hypothetical protein -
LQV29_RS07440 (1497121) 1497121..1497351 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV29_RS07445 (1497348) 1497348..1497764 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV29_RS07450 (1497920) 1497920..1498900 + 981 WP_032433385.1 hypothetical protein -
LQV29_RS07455 (1499095) 1499095..1500666 - 1572 WP_032433383.1 AAA family ATPase -
LQV29_RS07460 (1500985) 1500985..1501233 + 249 WP_032433382.1 hypothetical protein -
LQV29_RS07465 (1501292) 1501292..1501810 + 519 WP_045326794.1 hypothetical protein -
LQV29_RS07470 (1501841) 1501841..1502332 + 492 WP_032433378.1 hypothetical protein -
LQV29_RS07475 (1502392) 1502392..1502595 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1484035..1525340 41305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296242 WP_032433387.1 NZ_OW970357:1497348-1497764 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296242 WP_001261276.1 NZ_OW970357:1497121-1497351 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References