Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 82699..83225 Replicon plasmid P1
Accession NZ_OW969913
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LQ196_RS26745 Protein ID WP_000323025.1
Coordinates 82938..83225 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag LQ196_RS26740 Protein ID WP_004196370.1
Coordinates 82699..82938 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS26705 78036..78228 - 193 Protein_98 MFS transporter -
LQ196_RS26710 (AN2340V1_5115) 78258..79235 + 978 WP_004196334.1 chromate resistance protein -
LQ196_RS26715 (AN2340V1_5116) 79192..80568 + 1377 WP_004196363.1 chromate efflux transporter -
LQ196_RS26720 (AN2340V1_5117) 80599..81288 - 690 WP_004196322.1 hypothetical protein -
LQ196_RS26725 (AN2340V1_5118) 81302..82039 - 738 WP_008460272.1 HupE/UreJ family protein -
LQ196_RS26730 (AN2340V1_5119) 82083..82448 - 366 WP_009651956.1 hypothetical protein -
LQ196_RS26735 82576..82674 - 99 Protein_104 protein YdfV -
LQ196_RS26740 (AN2340V1_5120) 82699..82938 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LQ196_RS26745 (AN2340V1_5121) 82938..83225 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LQ196_RS26750 (AN2340V1_5122) 83297..83455 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
LQ196_RS26755 (AN2340V1_5123) 84061..85035 + 975 WP_004196336.1 hypothetical protein -
LQ196_RS28120 (AN2340V1_5124) 85019..85141 + 123 WP_254911979.1 hypothetical protein -
LQ196_RS26760 (AN2340V1_5125) 85233..85610 - 378 WP_045289277.1 hypothetical protein -
LQ196_RS26765 (AN2340V1_5127) 86096..87304 - 1209 WP_015344990.1 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 86096..87304 1208
- inside Non-Mobilizable plasmid - - 1..298591 298591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T296230 WP_000323025.1 NZ_OW969913:82938-83225 [Klebsiella variicola]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT296230 WP_004196370.1 NZ_OW969913:82699-82938 [Klebsiella variicola]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References