Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 35505..36415 | Replicon | plasmid P1 |
| Accession | NZ_OW969913 | ||
| Organism | Klebsiella variicola isolate 0 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2N4Z2R0 |
| Locus tag | LQ196_RS26455 | Protein ID | WP_004197882.1 |
| Coordinates | 35945..36415 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | LQ196_RS26450 | Protein ID | WP_004181895.1 |
| Coordinates | 35505..35948 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ196_RS26430 | 32571..32786 | - | 216 | Protein_42 | IS200/IS605 family transposase | - |
| LQ196_RS26435 (AN2340V1_REPA000000071) | 32788..33357 | + | 570 | Protein_43 | transposase | - |
| LQ196_RS26440 (AN2340V1_5064) | 33711..34133 | + | 423 | WP_004197884.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| LQ196_RS26445 (AN2340V1_5065) | 34133..35404 | + | 1272 | WP_004197886.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| LQ196_RS26450 (AN2340V1_5066) | 35505..35948 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| LQ196_RS26455 (AN2340V1_5067) | 35945..36415 | + | 471 | WP_004197882.1 | RES family NAD+ phosphorylase | Toxin |
| LQ196_RS26460 (AN2340V1_5068) | 36525..36785 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| LQ196_RS26465 (AN2340V1_5069) | 37347..38528 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
| LQ196_RS26470 (AN2340V1_REPA000000067) | 38673..39806 | + | 1134 | Protein_50 | IS1202-like element ISEsa1 family transposase | - |
| LQ196_RS26475 (AN2340V1_5071) | 39859..40563 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LQ196_RS26480 (AN2340V1_5072) | 40628..40990 | + | 363 | Protein_52 | OsmC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..298591 | 298591 | |
| - | inside | IScluster/Tn | - | - | 32971..40563 | 7592 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17633.92 Da Isoelectric Point: 4.5152
>T296229 WP_004197882.1 NZ_OW969913:35945-36415 [Klebsiella variicola]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDFFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDFFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT296229 WP_004181895.1 NZ_OW969913:35505-35948 [Klebsiella variicola]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N4Z2R0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |