Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5365050..5365675 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name vapC Uniprot ID A0A1F2M041
Locus tag LQ196_RS25855 Protein ID WP_008807903.1
Coordinates 5365050..5365433 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQ196_RS25860 Protein ID WP_162550505.1
Coordinates 5365433..5365675 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS25840 (AN2340V1_4952) 5362416..5363318 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LQ196_RS25845 (AN2340V1_4953) 5363315..5363950 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
LQ196_RS25850 (AN2340V1_4954) 5363947..5364876 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQ196_RS25855 (AN2340V1_4955) 5365050..5365433 - 384 WP_008807903.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ196_RS25860 (AN2340V1_4956) 5365433..5365675 - 243 WP_162550505.1 CopG family transcriptional regulator Antitoxin
LQ196_RS25865 (AN2340V1_4957) 5365880..5366797 + 918 WP_032741512.1 alpha/beta hydrolase -
LQ196_RS25870 (AN2340V1_4958) 5366812..5367753 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
LQ196_RS25875 (AN2340V1_4959) 5367798..5368235 - 438 WP_008807906.1 D-aminoacyl-tRNA deacylase -
LQ196_RS25880 (AN2340V1_4960) 5368232..5369092 - 861 WP_008807907.1 virulence factor BrkB family protein -
LQ196_RS25885 (AN2340V1_4961) 5369086..5369685 - 600 WP_008807908.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296228 WP_008807903.1 NZ_OW969912:c5365433-5365050 [Klebsiella variicola]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYELHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9524.80 Da        Isoelectric Point: 4.2500

>AT296228 WP_162550505.1 NZ_OW969912:c5365675-5365433 [Klebsiella variicola]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDLAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M041

Antitoxin

Source ID Structure

References