Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5044743..5046424 | Replicon | chromosome |
| Accession | NZ_OW969912 | ||
| Organism | Klebsiella variicola isolate 0 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | LQ196_RS24375 | Protein ID | WP_230138731.1 |
| Coordinates | 5044743..5045660 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A0B7GCX3 |
| Locus tag | LQ196_RS24380 | Protein ID | WP_008807257.1 |
| Coordinates | 5045666..5046424 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ196_RS24355 (AN2340V1_4676) | 5040049..5041569 | + | 1521 | WP_008807253.1 | sugar ABC transporter ATP-binding protein | - |
| LQ196_RS24360 (AN2340V1_4677) | 5041566..5042564 | + | 999 | WP_050887563.1 | ribose ABC transporter permease | - |
| LQ196_RS24365 (AN2340V1_4678) | 5042595..5043536 | + | 942 | WP_117133573.1 | ABC transporter substrate-binding protein | - |
| LQ196_RS24370 (AN2340V1_4679) | 5043611..5044618 | + | 1008 | WP_230138730.1 | carbohydrate kinase family protein | - |
| LQ196_RS24375 (AN2340V1_4680) | 5044743..5045660 | - | 918 | WP_230138731.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LQ196_RS24380 (AN2340V1_4681) | 5045666..5046424 | - | 759 | WP_008807257.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LQ196_RS24385 (AN2340V1_4682) | 5046509..5047237 | - | 729 | WP_008807258.1 | response regulator transcription factor | - |
| LQ196_RS24390 (AN2340V1_4684) | 5047510..5049657 | + | 2148 | WP_077598880.1 | formate dehydrogenase subunit alpha | - |
| LQ196_RS24395 (AN2340V1_4685) | 5050275..5050961 | + | 687 | WP_008807260.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34767.13 Da Isoelectric Point: 5.4707
>T296227 WP_230138731.1 NZ_OW969912:c5045660-5044743 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIASNLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIASNLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28653.01 Da Isoelectric Point: 10.1988
>AT296227 WP_008807257.1 NZ_OW969912:c5046424-5045666 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|