Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2718325..2719913 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag LQ196_RS13240 Protein ID WP_008804919.1
Coordinates 2718325..2719647 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag LQ196_RS13245 Protein ID WP_008804920.1
Coordinates 2719647..2719913 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS13225 (AN2340V1_2532) 2713390..2715891 + 2502 WP_087653149.1 fimbria/pilus outer membrane usher protein -
LQ196_RS13230 (AN2340V1_2533) 2715879..2716883 + 1005 WP_060875807.1 fimbrial protein -
LQ196_RS13235 (AN2340V1_2534) 2717016..2718308 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
LQ196_RS13240 (AN2340V1_2535) 2718325..2719647 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
LQ196_RS13245 (AN2340V1_2536) 2719647..2719913 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQ196_RS13250 (AN2340V1_2537) 2720179..2720505 - 327 WP_008804921.1 hydroxyisourate hydrolase -
LQ196_RS13255 (AN2340V1_2538) 2720502..2721002 - 501 WP_064170224.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQ196_RS13260 (AN2340V1_2539) 2720980..2722359 - 1380 WP_109848847.1 nucleobase:cation symporter-2 family protein -
LQ196_RS13265 (AN2340V1_2540) 2722705..2723859 + 1155 WP_148665841.1 FAD-dependent urate hydroxylase HpxO -
LQ196_RS13270 (AN2340V1_2541) 2723840..2724763 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T296223 WP_008804919.1 NZ_OW969912:c2719647-2718325 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT296223 WP_008804920.1 NZ_OW969912:c2719913-2719647 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References