Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1581783..1582780 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQ196_RS07700 Protein ID WP_230138501.1
Coordinates 1582226..1582780 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag LQ196_RS07695 Protein ID WP_012541033.1
Coordinates 1581783..1582229 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS07680 (AN2340V1_1467) 1578078..1579076 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LQ196_RS07685 (AN2340V1_1468) 1579195..1580715 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LQ196_RS07690 (AN2340V1_1469) 1580731..1581741 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
LQ196_RS07695 (AN2340V1_1470) 1581783..1582229 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
LQ196_RS07700 1582226..1582780 - 555 WP_230138501.1 HipA domain-containing protein Toxin
LQ196_RS07705 (AN2340V1_1471) 1582809..1583330 - 522 WP_032740372.1 hypothetical protein -
LQ196_RS07710 (AN2340V1_1472) 1583445..1584176 - 732 WP_008804033.1 outer membrane permeability protein SanA -
LQ196_RS07715 (AN2340V1_1473) 1584469..1585353 - 885 WP_012541034.1 cytidine deaminase -
LQ196_RS07720 (AN2340V1_1474) 1585482..1586177 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
LQ196_RS07725 (AN2340V1_1475) 1586167..1586571 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20697.98 Da        Isoelectric Point: 5.7891

>T296217 WP_230138501.1 NZ_OW969912:c1582780-1582226 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT296217 WP_012541033.1 NZ_OW969912:c1582229-1581783 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References