Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 762127..762784 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LQ196_RS03765 Protein ID WP_002916310.1
Coordinates 762374..762784 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LQ196_RS03760 Protein ID WP_002916312.1
Coordinates 762127..762393 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS03735 (AN2340V1_0717) 758458..759192 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
LQ196_RS03740 (AN2340V1_0718) 759243..759554 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
LQ196_RS03745 (AN2340V1_0719) 759719..760378 + 660 WP_008806429.1 hemolysin III family protein -
LQ196_RS03750 760444..760851 + 408 WP_230138420.1 hypothetical protein -
LQ196_RS03755 (AN2340V1_0720) 760898..761881 - 984 WP_032731234.1 tRNA-modifying protein YgfZ -
LQ196_RS03760 (AN2340V1_0721) 762127..762393 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LQ196_RS03765 (AN2340V1_0722) 762374..762784 + 411 WP_002916310.1 protein YgfX Toxin
LQ196_RS03770 (AN2340V1_0723) 762791..763312 - 522 WP_008806427.1 flavodoxin FldB -
LQ196_RS03775 (AN2340V1_0724) 763413..764309 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
LQ196_RS03780 (AN2340V1_0725) 764332..765045 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ196_RS03785 (AN2340V1_0726) 765051..766784 + 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296215 WP_002916310.1 NZ_OW969912:762374-762784 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296215 WP_002916312.1 NZ_OW969912:762127-762393 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References