Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 274137..274768 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H4S6Z2
Locus tag LQ196_RS01235 Protein ID WP_008806943.1
Coordinates 274137..274412 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7H4S6Z1
Locus tag LQ196_RS01240 Protein ID WP_023298308.1
Coordinates 274409..274768 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS01215 (AN2340V1_0235) 269373..269708 + 336 WP_002921203.1 universal stress protein UspB -
LQ196_RS01220 (AN2340V1_0236) 269768..271264 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
LQ196_RS01225 (AN2340V1_0237) 271494..272687 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
LQ196_RS01230 (AN2340V1_0238) 272727..273740 - 1014 WP_012540371.1 magnesium transporter -
LQ196_RS01235 (AN2340V1_0239) 274137..274412 + 276 WP_008806943.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ196_RS01240 (AN2340V1_0240) 274409..274768 + 360 WP_023298308.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ196_RS01245 (AN2340V1_0241) 274796..275197 - 402 WP_048268290.1 nickel-responsive transcriptional regulator NikR -
LQ196_RS01250 (AN2340V1_0242) 275185..275976 - 792 WP_230138398.1 nickel import ATP-binding protein NikE -
LQ196_RS01255 (AN2340V1_0243) 275973..276737 - 765 WP_023340796.1 nickel import ATP-binding protein NikD -
LQ196_RS01260 (AN2340V1_0244) 276737..277570 - 834 WP_230138399.1 nickel ABC transporter permease subunit NikC -
LQ196_RS01265 (AN2340V1_0245) 277567..278511 - 945 WP_016161924.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10295.87 Da        Isoelectric Point: 10.3900

>T296212 WP_008806943.1 NZ_OW969912:274137-274412 [Klebsiella variicola]
MEQQVLSLRNKQRHTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVRP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13341.08 Da        Isoelectric Point: 4.4605

>AT296212 WP_023298308.1 NZ_OW969912:274409-274768 [Klebsiella variicola]
MIKPKTPNSMEIAGQPAVINYVPELNVFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4S6Z2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4S6Z1

References